a tool for identifying drug-targetable redox-active disulphides

H-2 class II histocompatibility antigen, I-A beta chain

Intramolecular

Cysteine 144 and cysteine 200

A redox-regulated disulphide may form within H-2 class II histocompatibility antigen, I-A beta chain between cysteines 144 and 200.

Details

Redox score ?

80

PDB code

Structure name

evidence that structural rearrangements and/or flexibility during tcr binding can contribute to t-cell activation

Structure deposition date

2003-10-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

78

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

144

Residue number B

200

Peptide name

H-2 class II histocompatibility antigen, I-A beta chain

Ligandability

Cysteine 144 of H-2 class II histocompatibility antigen, I-A beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of H-2 class II histocompatibility antigen, I-A beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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